Epidermal cyclic AMP is not decreased in psoriasis lesions.

Molecular and clinical pharmacology of psoriasis.

Psoriasis appears in most cases to be a genetic disease in which stratified squamous epithelium (epidermis) of skin in involved versus normal-appearing uninvolved areas has the following prototypic features: (1) excessive cell proliferation and an accelerated cell cycle of the proliferating cells '; (2) incomplete epidermal specialization (keratinization) for tissue function; and (3) marked inc...

Evaluation of plasma lipids and lipoproteins in patients with psoriasis

Psoriasis is an epidermal disease characterized by chronic relapsing papillon squamous erythematous plaques which may develop in the skin of elbows, knees and extensor surfaces. The cause of psoriasis is unknown. The primary etiologic factor may be related to excessive uncontrolled synthesis is resulting from changes in (1) the function of growth factors ( EGF),(2) presence of proto- oncogenes,...

The Epidermis and Cyclic Amp

A hormone induces a rapid and profound change in the metabolic balance of its target organ. Early studies emphasized the extraordinarily low concentrations in which many hormones are effective. The fact that catechoiamines and polypeptides are frequently unable to penetrate the surface of cells made this seem all the more remarkable. The mechanism of their action, which for many years remained ...

Printed in Great Britain INCREASED CYCLIC GMP AND DECREASED CYCLIC AMP LEVELS IN THE HYPERPLASTIC, ABNORMALLY DIFFERENTIATED EPIDERMIS OF PSORIASIS

Colocalization of Vitiligo and Verrucous Epidermal Nevus: A Simulator of Depigmented Variant of Verrucous Epidermal Nevus

Vitiligo, an autoimmune disorder, is known to co-localize with other immunological disorders like lichen planus and psoriasis. However, there are no reports regarding the co-localization of an autoimmune disorder (vitiligo) and a developmental disorder (verrucous epidermal nevus). We hereby present a 10-month-old infant who was visited for white patches on the right buttock and adjoining antero...